The particular protein I have chosen, shown here at the left is the Foot-And-Mouth Disease Virus Oligosaccharide Receptor Complex. Located on this structure are many difulside bonds. When these bonds are in a state of reduction, the virus can maintain its infectivity which is a key factor of the virus life cycle. This protein also contains four sub-units; each of which contains beta pleated sheets depicted by yellow arrows while alpha helixes are presented by green crayons. Three of which sub-units are categorized as being part of the RHV-like superfamily. The RHV-like superfamily also contains the Seneca Valley Virus-100 along with many other virus proteins. This particular virus shares 179 amino acids with the Foot-And-Mouth Virus. Th
e fourth sub-unit categorized as being part of the DUF-1865 superfamily. DUF stands for Domain of Unknown Function and is commonly found in viral proteins. The picture on the right depicts the DUF-1864 amino acid protein. Real world applications include research of the viral life cycle with respect to quaternary structure and methodoligies in the inhibition of replication of such viruses.
e fourth sub-unit categorized as being part of the DUF-1865 superfamily. DUF stands for Domain of Unknown Function and is commonly found in viral proteins. The picture on the right depicts the DUF-1864 amino acid protein. Real world applications include research of the viral life cycle with respect to quaternary structure and methodoligies in the inhibition of replication of such viruses.Photos can be directly viewed at http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=149869 and http://www.ncbi.nlm.nih.gov/Structure/mmdb/mmdbsrv.cgi?uid=1QQP
What exactly does the RHV - like superfamily consist of?
ReplyDeleteHi - just curious, what is the part of the virus's life cycle that makes the infectivity so important? Is it that the virus cannot survive unless it infects its victim?
ReplyDeleteVery interesting info about the Foot-And-Mouth Disease Virus Oligosaccharide Receptor Complex.
I really liked this blog. I think it was nicley done with having the picture included. I found this protein to be interesting since it has a domian of unknown origin. Do you know if the bonds are commonly in state of reduction or only when its about to infect the host with the virus?
ReplyDeleteNicely done!
GTT- I am familiar with the way anit-virals such as famciclovir, valtrex (valacyclovir), and more commonly known Tamiflu, work within the body. Any anti-viral must be taken within 48 hours of onset because these drugs work by lysing the cells infected by a virus at the point before replication and assembly thus, preventing replication of the virus.
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