Tuesday, February 23, 2010

What knowledge have you connected with past knowledge?

Before taking Biochemistry I knew of enzymes and some of their properties. Mostly I remember the Lock&Key analogy. However I didn't know that as of more recently, enzymes are thought to utilize an Induced Fit mechanism. This means that an enzyme can conform to several subtrates, not just 1 specific substrate as previously thought. Zymogens are enzymes that serve a function of rendering particular precursor enzymes irreversibly inactive. This is important because our body creates certain precursors that can be harmful and therefore must be inactivated and preferrably irreversively. While learning about the foot-and-mouth disease protein I am better able to understand the structure and what specific role the subunits play. Even subunits that have a domain of function that is still unknown, gets assigned a subunit label DUF; domain of unknown function. I am also very interested in phamacology and the way researchers can use what is known about enzymes to help them develop medicine that takes advantage of this knowledge. Since many proteins can be grouped by common subunits, this makes creating drugs easier by having one drug that works for multiple proteins.

2 comments:

  1. OK, I put it in my book marks. You have not overstated this site. It is as you say, "state of the art" or was it "cutting edge", either way, a person visiting and playing with this site is bound to learn a great deal and probably not even realize it.

    MCB

    ReplyDelete
  2. I appreciated this post because you referenced learning the lock and key analogy for enzyme substrate binding. I find it facinating how rapidly biochemistry is evolving. I took biology this past summer and the lock and key method was still being taught. I often wonder if we are just learning more detailed information as we progress in our schooling or scientist are discovering new information as fast as we are learning it.

    ReplyDelete